Édgar Ramírez and Mandy Moore Talk ‘Dr. Death’ Research and Takeaways: “No One Is Above Being Deceived”

The pair play surgeon Paolo Macchiarini and investigative journalist Benita Alexander, respectively, in the Peacock anthology series based on the Wondery true-crime podcast.

An investigative journalist falls for her subject: A handsome, world-renowned surgeon.

That logline could be the start of a rom-com. Instead, it’s the beginning of a sinister story, one that’s told on Dr. Death.

The second season of the Peacock anthology based on the Wondery podcast brings to screen the true-crime story of Paolo Macchiarini (played by Édgar Ramírez), the pioneering Italian surgeon whose revolutionary biosynthetic tracheas could be a medical solution to the traditional trachea transplant. His work is so impressive, he becomes the subject of a TV profile from New York journalist, and former NBC producer, Benita Alexander (Mandy Moore), who — spoiler alert — ends up contributing to a much more important Vanity Fair article that ultimately unmasks the real Paolo Macchiarini.

But in the time between their first encounter in 2013 and that 2016 article, the pair fall in love. A whirlwind romance of sorts ensues, where Alexander — who is grieving the death of her ex-husband, the father to her daughter — risks her career and reputation for what she believes to be true love. She is planning a fairytale wedding to be officiated by none other than the Pope, who counts himself among an admirer of Macchiarini’s.

And that is just one of several facts that seem too wild to be true, before their romance unravels in the latter half of the season, when Alexander and several whistleblowers — the Swedish medical team around Macchiarini — work in parallel stories to hold him accountable for the lies, manipulations and abuses of power that lead to several patient deaths — all of whom are named and whose stories are told across the eight episodes of Dr. Death.

For showrunner Ashley Michel Hoban, telling the patients’ stories was paramount to the series. “It was important for us to name the patients and tell their stories as closely as possible,” Hoban tells The Hollywood Reporter. “Obviously, those patients are no longer with us. But their stories are documented and we tried to honor them and their stories by sticking as closely to reality as possible.”

Of Alexander’s story running alongside the doctors who ultimately brought Macchiarini to justice, Hoban says “these two stories could be individually eight episodes. So, there was definitely time for us to dig into the world of the whistleblowers, and particularly dive into the world of the patients in a way that was an honor to tell their stories in the way that we were able to do.”

The whistleblowers were written as composite characters who are played by Luke Kirby, Ashley Madekwe and Gustaf Hammarsten in Dr. Death. While some of Macchiarini’s story has been told onscreen before — including weeks earlier with Netflix’s Bad Surgeon: Love Under the Knife docuseries — Hoban says that diving into the medical side is what sets their project apart.

“This series is based on the podcast, so we had all of that research, which was an amazing treasure trove of interviews and transcripts,” she says of the podcast interviews. “Then it was really about finding our most interesting way in, and that ended up being, I think, different. I haven’t seen the Netflix series, but I think we got to take all of the stories, especially on the medical side, and composite characters down to create a whole new world of these characters, so that people who know the story are going to get a different side of it with these new characters we’re introducing, and also a deeper dive into the patients’ experiences.”

When it came to casting their leads, Hoban says she wrote the part with Ramírez in mind (“Who speaks seven languages and can have the charm and the charisma and the intelligence?”), and she never thought Moore, who had her second child, son Ozzie, only six weeks before filming, would be in the position to say yes.

“I didn’t think in a million years she would want to jump back into something and move her family to New York for six months,” Hoban recalls. “And my god, she did and she did it so wonderfully. The nuance that she brings to screen is just incredible to watch. She’s got that thing.”

Moore, who had also just wrapped her six-season run as Rebecca Pearson on NBC hit This Is Us with a May 2022 finale, laughs when thinking back at the whirlwind decision. “I was high on oxytocin, I just had a baby! I was like, ‘Yes, I’ll do anything!’” she tells THR. “I got the call and I had a one-month-old baby. It’s shooting in New York imminently. I was like, cool, cool, probably not going to be the thing. And then I remember reading those first two scripts and I thought, Damnit! I really want to do it!”

She adds, “I think the combination of Édgar, the story we were telling, being in New York; it was an anthology, it was eight episodes. I’ve just never done anything like this. Tonally, it was so different. And I loved season one. I was like: This is a no-brainer, let’s do it.”

The decision left Moore with little prep time; only two weeks before filming, in fact. So she dove into the podcast for research and spoke to an investigative journalist friend to get an understanding around the demands of a job like Alexander’s: “How do you mine through what’s going to be a good story and how do you bring it to your bosses? That sort of stuff was fascinating to me, as well as figuring out who this mother was who just lost her ex-partner and now was truly a single parent, and how she was navigating the world around her and what made her particularly susceptible to this brand of manipulation. How did she sort of allow herself to be vulnerable enough that she could fall victim?”

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